Clinical Research
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The Clinical Study on the Anti-Wrinkle and Moisturizing Effects of Zizania latifolia Extract (DermaNiA®)
Abstract
Zizania latifolia known as wild rice has been used to treat a variety of ailments in oriental folk medicine. As if to back this up, it has been reported to possess various biological activities such as antioxidative, antiinflammatory, insulin resistance-improving and antihyperlipidermic effects. Recently, Z. latifolia showed the actions suggesting its efficacy on skin such as protection of skin fibroblasts from UV-induced damage and whitening effects. More interestingly, when this plant was given orally to mice, the increase in mechanical strength of the skin and the protection of UV-induced wrinkle formation were observed. However, its efficacy on human skin has not studied yet. In the present study, an attempt was made to investigate its anti-wrinkle and moisturizing effects on human skin using the extract of this plant named DermaNiA®. Women subjected aged 30 to 50 were randomly allocated into the 2 groups: 1) control group taking placebo capsules and 2) DermaNiA® group taking DermaNiA®capsule (125 mg/capsule) and each group was taking 2 capsules of each/day orally for 12 weeks and then skin moisture, wrinkle parameters and anthropometry parameters were measured at 0, 4, 8, and 12 weeks. Changes in moisture in the cheek and interior forearm areas were observed with time in both groups. After 12 weeks, moisture in the cheek was more significantly improved in the DermaNiA® group than that in the control group (P=0.037). Wrinkle counts were also significantly reduced in the DermaNiA® group (P=0.016). The oral administration for 12 weeks did not show any changes on the blood chemistry. Our findings suggest that DermaNiA® might be beneficial for improving the wrinkle and moisture statuses and thus, could be used as a functional food.
